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Three GLP-1 agonists have been approved for weight loss, including liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound).
Semaglutide (Wegovy) was also recently to reduce the risk of heart attack, stroke, and cardiovascular death in adults with heart disease and overweight or obesity. Buy Weight Loss Pills
All three medications are available as a self-administered injection, but liraglutide is administered once daily, while semaglutide and tirzepatide are only injected once per week.
Though not approved specifically for weight loss, some other GLP-1 agonists intended to treat type 2 diabetes are sometimes prescribed off-label for weight management, including :
- semaglutide (Ozempic or Rybelsus)
- dulaglutide (Trulicity)
- liraglutide (Victoza)
- exenatide (Byetta)
- exenatide extended-release (Bydureon BCise)
- tirzepatide (Mounjaro)
GLP-1 agonists are only available through a prescription from a doctor or other qualified healthcare professional. Several telehealth services and weight loss programs may also provide prescriptions if you meet the eligibility criteria.
How it works: GLP-1 agonists work by binding to GLP-1 receptors to mimic the effects of GLP-1, a hormone that helps stomach emptying, increase feelings of fullness, and reduce the secretion of glucagon, which is involved in regulating appetite. Tirzepatide works similarly to other GLP-1 medications but binds to both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors.
Current list price: GLP-1 medications range from $250 to $750 per month, depending on the medication, dose, and pharmacy. The out-of-pocket cost can vary depending on what insurance covers.
Effectiveness: One study with 1,961 adults found that taking 2.4 milligrams (mg) of semaglutide per week combined with lifestyle changes resulted in a nearly 15% reduction in body weight after 68 weeks. More recently, a 2023 phase 3 clinical trial in 2,539 adults found that people taking tirzepatide lost 20% or more of their weight over the course of 72 weeks.
Many companies offer GLP-1 medication through their online services. Here’s one option Click To Shop
Naltrexone/bupropion (Contrave)
This medication, Buy Weight Loss Pills sold under the name Contrave, is an oral medication that bupropion, an antidepressant, and naltrexone, which is used to manage opioid or alcohol use disorder. Buy Weight Loss Pills
A doctor can determine whether Contrave may be a good option for you and then provide a prescription. Some online services may also prescribe Contrave following a virtual consultation with a healthcare professional. Buy Weight Loss Pills
How it works: Though the exact mechanism of naltrexone/bupropion isn’t fully understood, it’s believe weight loss by acting on certain parts of the brain to reduce food intake, Buy Weight Loss Pills boost metabolism, and increase feelings of fullness.
Effectiveness: One review of four studies showed that naltrexone/bupropion was associated with significant weight loss compared with a placebo, Buy Weight Loss Pills with participants losing an average of 11 to 22 lb (5 to 9 kg).
Setmelanotide (Imcivree)
Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 (MC4) receptor agonists. It’s an injectable medication for treating obesity caused by certain genetic mutations and is available only via prescription.
How it works: People with specific genetic mutations may experience insufficient activation of melanocortin receptors in the brain, which could contribute to obesity.
Setmelanotide works by increasing the activation of these receptors, leading to reduced hunger, decreased calorie intake, and increased metabolism, all of which could promote weight loss.
Effectiveness: Two trials involving 21 people taking setmelanotide found that around 62% of them achieved at least 10% weight loss after 1 year. Participants also experienced a significant reduction in hunger with no serious treatment-related adverse events reported. Buy Weight Loss Pills
Another small study in children, adolescents, and adults found that setmelanotide significantly improved quality of life as early as 5 weeks after starting treatment, which could be related to reduced hunger and body weight.
Pros
- effective for weight loss when used alongside dietary changes and regular physical activity
- FDA approved for weight management
- might offer other health benefits, including improved blood sugar, blood pressure, or cholesterol levels
- many medications available through orderweightlosssolutions.com
Cons
- not suitable for everyone, including individuals with certain health conditions or eating disorders
- could interact with some medications
- should not be used by people who are pregnant or breastfeeding
- some medications may be expensive, depending on insurance coverage
- can cause side effects, some of which may be serious
- increased risk of toxicity if taken in high doses
- weight regain is possible once medication is discontinued
- more research needed on long-term health effects
Most weight loss medications are approved for adults with obesity or with overweight and at least one weight-related condition, such as:
- type 2 diabetes
- high blood pressure
- high cholesterol
Similarly, setmelanotide (Imcivree), is intended to treat obesity caused by certain genetic disorders.
These medications are designed for people who haven’t been able to achieve weight loss through other methods, including diet or lifestyle changes. Buy Weight Loss Pills
Though they shouldn’t be considered a quick fix, these medications can be a useful tool to support weight management when combined with regular physical activity and a nutritious diet. Buy Weight Loss Pills
Keep in mind that weight loss medications are not suitable for everyone, including but not limited to:
- people who are pregnant or breastfeeding
- people with certain health conditions
- people taking specific medications
- people with eating disorders or disordered eating symptoms
A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status.